Endocrine Abstracts

Purpose: Coronary artery disease (CAD) is more common and severe in diabetic patients. The aim of this study is to assess the frequency of silent myocardial ischemia in asymptomatic diabetitics by myocardial perfusion scintigraphy and to correlate the results with risk fators.Methods: We prospectively studied 50 (25 men and 25 women) diabetic patients asymptomatic and without known history of CAD. The minimum duration of diabetes was 15 years for the typ...

Extracellular matrix protein 1 (ECM1) is an 85 kDa glycoprotein that plays an important role in skin physiology, angiogenesis, tumor progression and malignancies. However, the function of ECM-1 in regulation of the immune responses has not been identified. Recent studies showed ECM-1 deficiency lowers the capacity of T helper 2 (Th2) cells to emigrate from draining lymph nodes to an inflamatory site. Lipoid proteinosis (LiP) and Licken Sclerosus (LS) are immunogenetic counterp...

Objectives: Pituitary Apoplexy, either as a result of haemorrhage or infarction, remains a rare but serious Endocrine Disorder, requiring urgent clinical assessment and management. The British Endocrine Society (BES) has set out recommendations regarding the diagnosis and management of pituitary apoplexy, but there remains little published literature depicting this. The aim of this study was to compare our current Management practise of Pituitary Apoplexy with the recommendati...

Background: The treatment of choice for primary hyperparathyroidism (PHPT) is surgical parathyroidectomy. Cinacalcet is the first calcimimetic approved by European Medicines Agency (EMA) in 2008 for use in patients with PHPT who are not fit for surgery or refuse surgery. British National Formulary (BNF) recommends it for hypercalcaemia in PHPT where parathyroidectomy is inappropriate. The main aim of treatment with cinacalcet is to keep calcium levels at safe levels.<p cla...

We report a 55-year-old non-smoker with a history of Graves’ disease diagnosed in 1990 at age 29 years old. Due to poor compliance to therapy, she underwent a total thyroidectomy within 1 year of diagnosis. She remained well controlled on thyroid hormone replacement for over 20 years with Levothyroxine 100 μg daily. However, in the two years before referral to the Endocrine Clinic, she had difficult to treat hypothyroidism with persistent over-replacement; at the tim...

Background-aim: Tendency to autoimmune diseases has been reported to be increased in beta thalassemia minor (BTM). Our aim was to examine the prevalence of thyroid autoimmunity in BTM.Method: Eighty six adults with BTM and 93 age and gender matched controls were included in the study. The two groups were compared cross-sectionally in terms of anti-thyroid antibodies (anti-TG and anti-TPO) and thyroid hormones. Patients with known autoimmune disorders oth...

Background: Subacute thyroiditis (SAT) is a transient inflammatory, probably viral disease of the thyroid gland. It is clinically characterized by pain, fever, increased erythyrocyte sedimentation rate (ESR) or other markers of inflammation, transient thyrotoxicosis, and has a tendency to recur. In most cases, in addition to the clinical features, scintigraphy and ultrasound may support the diagnosis of SAT. However, in the present case, SAT with an atypical thyroid 99m</...

We present a 50-year-old man who was referred to endocrine clinic with painful gynaecomastia of 3 months duration. He was waiting hip replacement. He had history of a lump in his left breast 9 years ago. He had USS and FNA. He was treated with some tablets for a month and discharged from breast clinic. He had no other past medical history. He worked as a physical trainer to metropolitan police. He did not smoke or drink and was on no medication. He had never used recreational ...

Thyroidectomy is a definitive form of treatment for patients with hyperthyroid Graves’ disease particularly those who are noncompliant with or have serious side effects to the antithyroid drugs, have very large goitres, refuse 131I therapy or, have moderate to severe ophthalmopathy. The risk of perioperative thyroid storm is usually higher following an acute event such as surgery, trauma, or infection. Thus, patients with thyrotoxicosis presenting for surgery should ideal...

We report a 55 year old non-smoker with a history of Graves’ disease diagnosed in 1990 at age 29 years old. Due to poor compliance to therapy, she underwent a total thyroidectomy within 1 year of diagnosis. She remained well controlled on thyroid hormone replacement for over 20 years with Levothyroxine 100 μg daily. However, in the 2 years before referral to the Endocrine Clinic, she had difficult to treat hypothyroidism with persistent over-replacement; at the time ...